Saturday 22 August 2020

Subjective side of replicating molecule and its Evolution

The replicating molecule that was precursor to first cell must have felt urge to combine with particles that were similar to itself and that it was capable of attracting. When it succeeded in combining molecules to itself, it must had a sense of relief, of tension subsiding. (Naturally, charged chemical molecules always are tensed and are in search of a way to ease this tension. The tension eases when they combine with opposite charged compatible molecule.) Such feelings/sensations of tension and relief were the subjective side of those molecules.

When one molecule came and attached to replicating molecular structure, it was feeling one type of forces around it. When another molecule came and attached to replicating structure next to this first molecule, first molecule feels a change of force around it. Its feeling changes. Now its destiny is linked to the other molecule. With each coming molecule, the force around first molecule changes and that's reflected in change of feeling it feels. Its urge, its attracting power changes. Finally when all molecules are attached to replicating structure, they are in shape similar to original replicating structure. When new structure separates from original structure, the overall feeling it feels is similar to the overall feeling of original structure. That's because molecular composition and shape and structure is similar. So the force around it is similar. The attraction and charge it has is similar. Now the feeling of our first molecule is morphed in a way that it is part of overall feeling of structure. That's because the force and charge our first molecule has around it is morphed due to other molecules around it. That overall new molecular structure has a resultant force and charge (attraction).

The world of a charged element or molecule must be quite chaotic. It feels a constant craving to satisfy the deficiency (in case of negative charge) or excess (in case of positive charge) it constantly feels. It attracts the first compatible opposite charged element/molecule that comes near it through electromagnetic force and combines with it to form a new molecule. The resultant molecule may be stable or it may also have some charge. If it has charge, it will again seek to combine with any compatible opposite charged molecule. All this leads to many different molecular structures with different properties. One such structure may have been a bit long and may have a property of replication. It attracted only molecules similar to its own constituent molecules, but when they all combined, it felt a repulsive force and released the new structure away. Once alone, it again attracted, then again released. Thus the cycle went on and the original structure became a replicating machine. All the structures it was releasing were similar to itself and they all became replicating machines too and thus the number of these replicating molecular structures increased exponentially, provided constituent molecules were available in abundance.


Replication with protective layer: Now, naked molecules may have gotten easily destroyed due to a variety of outside forces but lets say some of them accidentally got inside oil bubbles or other form of protective bubble. Those inside the bubbles were safe from variety of destructive outside forces. So bubble ones survived and naked ones got destroyed. Now we only have bubble enclosed replicating structures. They again started replicating if constituent molecules were able to flow inside those bubbles. When new structure separates from parent structure, it moves away with speed and as it reaches bubble boundary, it takes half the bubble with it. (Or it may be that bubble/molecular membrane was part of original molecular structure in the way it attracts molecules around it. Maybe, in addition to attracting similar constituent molecules, it also attracted some type of molecules around it in a circular fashion, like soap does around dust particles.) So when replication completes, bubbles/membrane also splits into two, around each structure. The bubble may be smaller at first but it would retain original bigger shape because of property/force of molecular structure and availability of raw material of bubble/membrane nearby.

Evolution: Lets say original molecular structure didn't have the property to form a protective membrane around it. The replications aren't perfect and error leads to some change in molecular structure of some copies (error may be due to a new molecule coming near and attaching somewhere to parent structure because it had properties similar to constituent molecule and thus was mistakenly accepted). Now let's say one such errored copy had a property of making molecular membrane around it. So this copy and copies of this copy had membrane around them while all other structures were naked. A destructive force or wave came from outside in the pool where all our molecular structures were propagating and killed all naked structures. But the structures with membrane survived due to protection from membrane. So from now on only membraned structures will be available in pool and they will replicate. Membrane became a fundamental part of our structure. This is evolution. A simple game of numbers and chance. All sorts of changes occur and propagate for time being, but only those changes that help in survival and propagation tend to survive in long term.

We today only see RNA and DNA, i.e. combination of nucleotides, but not any other simpler replicating structure. There must have been series of evolution of replicating structure that lead to RNA but probably previous ones didn't survive and only RNA ended up surviving or was stable enough to survive in long term. How did things come to RNA? RNA duplicates itself as well as releases proteins (made of amino acids - carbon based molecules) that help RNA in many ways - helping in replication as well as carrying out functions of RNA. How did it come to be? 

We do what we feel to do. To relieve this eternal craving we feel. Fill the gap / fill the hole as they say. Feelings change with events. Replicating molecule initially feels hunger. But when it manages to attract and attach all necessary particles to form a copy, maybe for a moment it is relieved, but then it feels the need to detach the complete copied molecule. Isn't it the same with us? We move from desire to desire. Once we attain a desire, for some small time we feel good but soon move on to next desire. Today's food can't satiate tomorrow's hunger. Why isn't the molecule ever satisfied? Because the day it is, it will be the end of its lineage. In the past, many forms of replicating molecule may have gotten satisfied/stabilized, then they no longer felt need to replicate and that was their lineage's end. Maybe even today they lie somewhere, gratified; more likely - external forces fragmented them away. 

But how did events turn into feelings? They were already feelings, only the feelings are now more segregated, specialized, as per the evolution. The hunger of molecule changed its "taste" as its shape changed. 

(A side idea that just came to me: Maybe particles don't 'have' feelings, maybe particles 'are' feelings.)

Initially the molecule controlled its structure from its own force. Then it started sending out smaller messengers/carriers/agent molecules to carry out work for it. How? An anomaly in molecule would've made it attract and then repel specific molecules and those molecules had some effects, say, weakening the protective layer during replication. Such change would've made that cell reproduce better/faster increasing its number and consequently chances of survival in a chaotic world, which it clearly did. Now that cell is bigger and has many molecules involved other than original replicating one, the feeling/force of cell as a whole is equal to resultant of feelings/forces of individual molecules. BUT only those cells will survive in which this resultant feeling is still of hunger and desire to replicate. This principal keeps eliminating those changes that lead cell to behave in any other way (i.e. cells with such changes don't replicate/survive). It may look difficult or improbable, but when you consider that those cells had many million years at their disposal, it becomes probable and even natural.